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It becomes even more important for practitioners to be careful about who should and should not be prescribed these medications, said Naval Vikram, a diabetologist and professor in the department of medicine of the All India Institute of Medical Sciences in New Delhi

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It would be great to undertake studies with the newer dual agonists and polyagonists also in rare obesity syndromes such as AS, Prader-Willi syndrome, and Bardet-Biedl syndrome (just to name a few) as the clinical need for effective obesity/hyperphagia therapies in these patients is especially high, says Scherer

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The other context where we use both is in longevity-focused protocols where the goal is comprehensive mitochondrial support rather than a single symptom target